癌症基因组图谱(The Cancer Genome Atlas Program ,TCGA)

发布时间:2023-12-22浏览量:

1. 数据集名称:

癌症基因组图谱(The Cancer Genome Atlas Program ,TCGA)

2. 数据集基本情况:

•项目背景:

–癌症基因组图谱(TCGA)是一项具有里程碑意义的癌症基因组计划,其分子特征表征了超过20,000种原发性癌症,并匹配了33种癌症类型的正常样本。这项国家癌症所(National Cancer Institute, NCI)和国家人类基因组研究所(National Human Genome Research Institute)的合作始于2006年,汇集了来自不同学科和多个机构的研究人员.

–起始年份:2006年

•样本量及癌症类型以及相关发表的文章:

–约11000个患者样本。

癌症类型

病例数

(典型文章(Marker Paper)中的病例数)

期刊/文章

急性髓系白血病: Acute Myeloid Leukemia

200 (200)

NEJM 2013

肾上腺皮质癌乳腺小叶癌Adrenocortical Carcinoma

92 (91)

Cancer Cell 2016

膀胱尿路上皮癌: Bladder Urothelial Carcinoma

412 (131)

Nature 2014, Cell 2017

乳腺导管癌: Breast Ductal Carcinoma

778 (430)

Nature 2012

乳腺小叶癌: Breast Lobular Carcinoma

201 (127)

Cell 2015

宫颈癌: Cervical Carcinoma

307 (228)

Nature 2017

胆管癌: Cholangiocarcinoma

51 (38)

Cell Reports 2017

大肠直肠腺癌: Colorectal Adenocarcinoma

633 (276)

Nature 2012

食管癌: Esophageal Carcinoma

185 (164)

Nature 2017

胃腺癌: Gastric Adenocarcinoma

443 (295)

Nature 2014

星形胶质瘤: Glioblastoma Multiforme

617 (206)

Nature 2008,Cell 2013

头颈部鳞状细胞癌: Head and Neck Squamous Cell Carcinoma

528 (279)

Nature 2015

肝细胞癌: Hepatocellular Carcinoma

377 (363)

Cell 2017

嫌色性肾细胞癌: Chromophobe Renal Cell Carcinoma

113 (66)

Cancer Cell 2014

透明细胞肾细胞癌: Clear Cell Renal Cell Carcinoma

537 (446)

Nature 2013

乳头状肾细胞癌: Papillary Renal Cell Carcinoma

291 (161)

NEJM 2016

低级别胶质瘤: Lower Grade Glioma

516 (293)

NEJM 2015

肺腺癌; Lung Adenocarcinoma

585 (230)

Nature 2014,Nature Genetics 2016

肺鳞状细胞癌: Lung Squamous Cell Carcinoma

504 (178)

Nature 2012,Nature Genetics 2016

间皮瘤: Mesothelioma

74 (87)

Cancer Discovery 2018

卵巢浆液性腺癌:Ovarian Serous Adenocarcinoma

608 (489)

Nature 2011

胰腺导管腺癌:Pancreatic Ductal Adenocarcinoma

185 (150)

Cancer Cell 2017

副神经节瘤和嗜铬细胞瘤:Paraganglioma & Pheochromocytoma

179 (173)

Cancer Cell 2017

前列腺癌:Prostate Adenocarcinoma

500 (333)

Cell 2015

肉瘤:Sarcoma

261 (206)

Cell 2017

皮肤黑色素瘤:Skin Cutaneous Melanoma

470 (331)

Cell 2015

睾丸生殖细胞癌:Testicular Germ Cell Cancer

150 (137)

Cell Reports 2018

胸腺瘤:Thymoma

124 (117)

Cancer Cell 2018

甲状腺乳头状癌:Thyroid Papillary Carcinoma

507 (496)

Cell 2014

子宫癌肉瘤:Uterine Carcinosarcoma

57 (57)

Cancer Cell 2017

子宫体子宫内膜样癌:Uterine Corpus Endometrioid Carcinoma

560 (373)

Nature 2013

葡萄膜黑色素瘤:Uveal Melanoma

80 (80)

Cancer Cell 2017

•数据类型:

–临床信息(如吸烟状况)

–分子分析物元数据(如样品分量)

–分子表征数据(如基因表达值)

注:更详细的分类见:https://www.cancer.gov/ccg/research/genome-sequencing/tcga/using-tcga-data/types

•要求/限制

–TCGA对隐私、使用做了非常详尽的说明,详见TCGA Ethics and Policies:https://www.cancer.gov/ccg/research/genome-sequencing/tcga/history/ethics-policies

3. 数据申请网站:

•NIHGDCDataPortal: https://portal.gdc.cancer.gov/

4. 申请流程:

进入网站,搜索自己需要的数据,直接下载。